Click amidations, esterifications and one–pot reactions catalyzed by Cu salts and multimetal–organic frameworks (M–MOFs)

• A Cu-catalyzed 100% atom–efficient amidation and esterification reaction based on the of cyclopropenones with amines or alcohols, is shown. Both soluble solid Cu catalysts are catalytically competent, a Cu-containing metal–organic framework (MOF) particularly active reusable. The can be performed in variety solvents conditions, including water at different pHs, which defined as click reaction. modular reactivity pattern (alkyl >> alkyl alcohols phenols aromatic amines) enables to design orthogonal one–pot reactions well–defined catalytic multimetal–MOFs (M–MOFs, M= Cu, Ni, Pd), easily functionalize resulting cinnamides cinnamic esters more complex molecules. Amides prevalent chemicals Nature, industry academic laboratories. Thus, it not surprising that plethora synthetic methods for these compounds has been developed along years. However, atom economical generally require harsh reagents conditions. Here we show “spring–loaded”, protocol consists ring opening alcohols. Some react spontaneously room temperature while other amines, presence amounts simple 2+ salts solids. Multimetal–Organic Frameworks strong resemblance conditions here reported copper–catalyzed azide–alkyne cycloaddition (CuAAC) allows define this fast, clean flexible